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Article
March 1954

MALIGNANT RETICULOENDOTHELIOSIS (LETTERER-SIWE DISEASE): Report of Case with Normocholesteremic Lipid Granulomatosis and Eosinophilic Granuloma

Author Affiliations

HILVERSUM, NETHERLANDS; BUSSUM, NETHERLANDS

AMA Am J Dis Child. 1954;87(3):328-336. doi:10.1001/archpedi.1954.02050090316008
Abstract

AFTER the publication of cases of eosinophilic granuloma of the skin, osseous forms, either solitary or multiple, began to attract the attention of clinicians in their attempt to find the relationship among the lipidoses, acute infective reticuloendotheliosis, and eosinophilic granuloma. We had the chance to study a very interesting case with fatal outcome in which biopsies and postmortem examination were possible, which gave a clue to two other cases of malignant reticuloendotheliosis published in 1950.

REPORT OF CASE  C. Kr., a girl, the second child of healthy parents without any hereditary trait or constitutional anomalies, was born after an uneventful pregnancy and parturition with a weight of 3,200 gm. The first child was a boy who had convulsions after sunstroke and suffered from attacks of bronchitis. Our patient was breast fed for a month, then artificial feeding was necessary. She thrived marvelously on acid milk (Karnemelk), and at the age

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