AS PREVIOUSLY reported from this clinic,1 the administration of a dietary supplement of reconstituted milk solids produced a significant increase in the rate of skeletal maturation in children with nutritive and growth failure. The overall increase in rate of skeletal maturation as measured by skeletal age (Todd2) and Red Graph (bone developmental age graph3) was obtained only when the level of supplementation was sufficient to overcome the deficiencies accumulated prior to giving the added milk. In making the assessments, it was noted that the growth response to the milk supplements was not equal in all bone centers. The skeletal growth progress of these children was characterized by a pronounced degree of asymmetry. It seemed of interest, therefore, to determine whether there was a differential utilization of the nutrients contained in the milk supplements by ossification centers in a selected skeletal area. In the present report, an analysis
DREIZEN S, SNODGRASSE RM, PARKER GS, CURRIE C, SPIES TD. MATURATION OF BONE CENTERS IN HAND AND WRISTOF CHILDREN WITH CHRONIC NUTRITIVE FAILURE: Effect of Dietary Supplements of Reconstituted Milk Solids. AMA Am J Dis Child. 1954;87(4):429–439. doi:10.1001/archpedi.1954.02050090417002
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