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June 1954

CORTICOTROPIN IN RHEUMATIC CARDITISBeneficial Effects of High Dosage and Short Duration in Acute Exacerbations of Chronic Rheumatic Carditis

AMA Am J Dis Child. 1954;87(6):694-701. doi:10.1001/archpedi.1954.02050090682004

SINCE 1949, when Hench1 first reported his results of the treatment of rheumatic fever with an adrenal cortex hormone, many investigators have employed cortisone and corticotropin (ACTH) to relieve both the exudative and the proliferative phases of the disease.

A study of the results reported demonstrates conclusively that the exudative aspects of rheumatic fever have been satisfactorily controlled, and generally the response has been much greater and more rapid than had been obtained with salicylates. The drop to normal in temperature, the slowing of the heart rate, the diminution of the erythrocyte sedimentation rate, the elimination of pain, redness, and swelling of the joints, the return to normal of the prolonged P-R interval, the shortening of the Q-T, the suppression of abnormal antibody responses, and the reversal of the altered albumin-globulin ratio, all have responded uniformly well to hormone therapy.

Unfortunately, no one has been able to state unequivocally

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