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June 1954

GROWTH AND METABOLISM IN NORMAL AND THYROID-ABLATED INFANT RHESUS MONKEYS (MACACA MULATTA): VII. Morphology of Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)—Skeletal System

Author Affiliations

From the Departments of Pediatrics and Pathology, University of California Medical School (Dr. Crane, Dr. Pickering, and Dr. Smyth) and the Department of Obstetrics and Gynecology, Yale University School of Medicine (Dr. van Wagenen).

AMA Am J Dis Child. 1954;87(6):708-723. doi:10.1001/archpedi.1954.02050090696006

INTRODUCTION  MORPHOLOGIC observations pertaining to the skeletal systems of normal and athyroid infant macaque monkeys are presented in the present communication, and certain correlations are made with preceding clinical, biochemical, and radiological observations on growth and metabolism in those animals.*Investigation of skeletal development in human cretinism is limited by multiple intrinsic and extrinsic factors which cannot be controlled. Experimental observations based on subprimates cannot always be applied to humans; therefore, it is logical to use a catarrhine laboratory animal in such studies. With selection of the primate Macaca mulatta for study, many intrinsic and extrinsic factors are subject to control.1The present study has been confined to early infancy, when growth and development is not only rapid but strikingly constant among normal colony members.† Control of extrinsic factors was facilitated by animal quarters which provided constant temperature, humidity, and physical environment. In addition, disease and nutritional deficiencies were

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