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Article
July 1954

LEUKEMIC XANTHOMATOSIS

AMA Am J Dis Child. 1954;88(1):43-61. doi:10.1001/archpedi.1954.02050100045006
Abstract

WE SHOULD like to present a heretofore unknown disease, "leukemic xanthomatosis." The condition is not familial or hereditary and is characterized by the following features:

  1. Xanthomatous skin lesions of the disseminated type and normal cholesterol blood levels.

  2. Development of generalized visceral reticuloendotheliosis with increased cholesterol tissue contents, a dense argyrophilic reticulum, and the appearance of foam cells—a histological picture similar to that of Hand-Schüller-Christian disease and its variants.

  3. Deposits of foci of primitive mesenchymal cells in the affected tissues—as commonly seen in leukemia—however, with many of these cells exhibiting a foamy protoplasm due to a high cholesterol content.

  4. Leukemic blood—and bone marrow findings and a fatal course as in leukemia.

  5. Numerous inclusion bodies were found in the organs of the presented case, and a virus was considered as a possible etiological agent.

In the aleukemic forms, the primitive stem cells do not differentiate into blood

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