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July 1954

CONGENITAL TOXOPLASMOSIS: Report of Case with Cataract, "Atypical" Vasopressin-Sensitive Diabetes Insipidus, and Marked Eosinophilia

Author Affiliations

From the Department of Pediatrics, Yale University School of Medicine.; Dr. Dixon's present address is Beeson Clinic, Wooster, Ohio.

AMA Am J Dis Child. 1954;88(1):84-91. doi:10.1001/archpedi.1954.02050100086011

CONGENITAL toxoplasmosis is being reported with increasing frequency and, in almost all cases, hydrocephalus or microcephalus, chorioretinitis, convulsions, and cerebral calcifications have been present.1 We wish to report a case of a 6-week-old infant with cerebral calcifications, with the unusual findings of unilateral cataract, hypernatremia, "atypical" vasopressin-(Pitressin-) sensitive diabetes insipidus, and marked eosinophilia of the peripheral blood and bone marrow.

REPORT OF CASE  M. V. H. entered the Grace-New Haven Community Hospital on June 5, 1953, at the age of 5½ weeks, because of lethargy, anorexia, and failure to gain weight. He had been born at term of a 23-year-old Rh-positive white mother whose serologic reactions for syphilis were negative. Labor and delivery were uneventful, and the mother said that she had not had a minor illness during pregnancy. At birth, the child had appeared normal, weighed 7 lb. 4 oz. (3,290 gm.), was 20 in. (50.8 cm.) long,