DIFFERENCES between the hemoglobin of the human fetus and adult have been known since 1866, when Von Korber ¶ demonstrated that fetal hemoglobin was more resistant to denaturation by alkaline solutions than was the adult type. Since then numerous investigations have confirmed the distinction between the two types of pigment and have pointed out physical, chemical, physiological, and immunological characteristics which serve to distinguish one from the other.# Most of the studies have indicated that the differences reside in the globin portion of the molecule, the heme apparently being identical in the two types of hemoglobin.37
In recent years Singer, Chernoff, and Singer38 have modified the method of alkali denaturation so that minute quantities of fetal hemoglobin can be detected with great accuracy. Results obtained in the study of normal infants and children with this more sensitive method have led to revision of previously established concepts. Thus Chernoff
SCHULMAN I, SMITH CH, STERN GS. I. FETAL AND ADULT HEMOGLOBIN IN PREMATURE INFANTS. AMA Am J Dis Child. 1954;88(5):568–575. doi:10.1001/archpedi.1954.02050100570002
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