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December 1954

CONGENITAL AFIBRINOGENEMIA: Report on a Child Without Fibrinogen and Review of the Literature

Author Affiliations

From the Departments of Pathology and Pediatrics of the Bowman Gray School of Medicine of Wake Forest College.

AMA Am J Dis Child. 1954;88(6):703-710. doi:10.1001/archpedi.1954.02050100705001

THE COMPLETE congenital absence of fibrinogen is apparently one of the most unusual anomalies, since only 21 cases have been reported to date.* In this presentation the 22d patient is discussed and a brief review appended. Aside from their rarity, these patients present findings which throw light on other, commoner problems and are examples of conditions which are impossible to produce experimentally at present.

A 19-day-old white boy, the child of unmarried parents, was referred to the North Carolina Baptist Hospital on Feb. 1, 1952, for the diagnosis and treatment of persistent bleeding from the umbilical cord. He was the second child of a 35-year-old mother, the product of a full-term gestation, without complications, with spontaneous delivery after an eight-hour labor in another city. The mother had been given 5 mg. of a vitamin K analogue prior to delivery. On the second day of life, oozing of blood from the

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