A great deal of evidence points to Group A hemolytic streptococci as being related to the cause of rheumatic fever.1 This does not explain, however, why only certain children develop the disease after having had streptococcal infections. It is well known that there is a high familial incidence present and that heredity may play a role. In addition, evidence is accumulating to show that the highest incidence of the disease with more serious complications occurs in children whose general health is suboptimal prior to the onset of the disease. Our research, therefore, has been directed toward the host factor, and inasmuch as we have been primarily interested in nutritional and metabolic studies, the problem has been approached from this standpoint. Studies in this clinic have shown that protein metabolism is altered, and the electrophoretic analysis of plasma or serum proteins of patients with rheumatic fever provides a sensitive
VAN LEEUWEN GJ, KELLY HG, JACKSON RL. Corticotropin and Cortisone in Rheumatic Fever: Preliminary Report of the Effect on the Electrophoretic Patterns of Plasma or Serum Proteins of Children. AMA Am J Dis Child. 1955;89(3):304–313. doi:10.1001/archpedi.1955.02050110370007
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