[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
April 1955

Marfan's Syndrome: Report of Five Cases in One Family

Author Affiliations


AMA Am J Dis Child. 1955;89(4):414-420. doi:10.1001/archpedi.1955.02050110504002

In the year 1896, A. B. Marfan1 first described the skeletal abnormalities of the syndrome which now goes by his name. Achard,2 in 1902, called attention to the marked attenuation of the extremities and their excessive length and because of the spiderlike appearance of the hands, called it arachnodactyly. He also was the first to report the familial occurrence of this disease. Salle,3 in 1912, first noted the association of the ocular and cardiac anomalies (confirmed by autopsy), and he called attention to an increase in the eosinophilic cells in the pituitary. Ormond and Williams4 focused attention on the frequent association of ectopia lentis and other ocular anomalies with arachnodactyly.

Piper and Irvine-Jones,5 in 1926, reported the first case in American literature. They stressed the frequency of association of arachnodactyly with congenital malformations of the heart. Weve,6 in 1931, called attention to the familial