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April 1955

I. Clinical Data

Author Affiliations

From Department of Research Medicine and Children's Hospital of University of Pittsburgh School of Medicine.

AMA Am J Dis Child. 1955;89(4):426-441. doi:10.1001/archpedi.1955.02050110516005

INTRODUCTION  The role of cortisone in prevention of residual cardiac damage following initial attacks of rheumatic heart disease is still not clear despite many reports of its administration.* The majority of the reports suggest that it was probably without value though the types of cases, their chronicity and severity, and the duration of cortisone dosage and its magnitude as well as associated therapy varied. At least several workers feel that this agent in conjunction with an adequate regimen is efficacious in controlling and preventing residual cardiac damage.† Our findings are in keeping with those of the latter group. This paper presents our experience with 53 children treated with large doses of cortisone in their initial attack of clinically unequivocal rheumatic carditis. The results suggest that cortisone in large amounts under the regimen employed may prevent cardiac abnormalities in patients without previous heart damage when given within six weeks of onset