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May 1955

Chlorpromazine in the Control of Vomiting in Children: Preliminary Clinical Evaluation

Author Affiliations

Houston, Texas
From the Department of Pediatrics, Baylor University College of Medicine, and the Pediatric Service, Jefferson Davis Hospital.

AMA Am J Dis Child. 1955;89(5):525-530. doi:10.1001/archpedi.1955.02050110639001

Vomiting is both a common and an important therapeutic problem in children. Every physician is aware of the extreme dehydration that may quickly follow its onset. A drug which appears to be a safe and effective agent for the control of vomiting is now available in the form of chlorpromazine hydrochloride* (10-[γ-dimethylaminopropyl]-2-chlorophenothiazine hydrochloride). Boyd and co-workers † and Cook and Toner3 have shown that this drug inhibits apomorphine-induced emesis in animals. These studies suggest that chlorpromazine acts by depressing the vomiting center within the central nervous system, thus blocking the vomiting reflex.

Several forms of side-reaction have been described in connection with chlorpromazine therapy. A sedative effect of variable degree is seen in the majority of successfully treated patients. This effect is most pronounced after the first dose and usually disappears within a few hours. Pharmacological studies by Moyer and co-workers4 reveal that in the usually administered therapeutic