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May 1955

I. Evidence of Abnormal Adrenal Cortex Function

Author Affiliations

Salt Lake City
From the Lockhart Memorial Laboratory, Department of Pediatrics, University of Utah School of Medicine, and the State Rheumatic Fever Clinics of the Utah State Department of Health.

AMA Am J Dis Child. 1955;89(5):575-579. doi:10.1001/archpedi.1955.02050110689009

The intimate relationship between chorea minor and rheumatic fever long has been recognized. The criteria of Jones,1 now accepted as standard for the diagnosis of rheumatic fever, include chorea as a major manifestation. Chorea has been reported to occur in 51% of all rheumatic fever patients during some phase of their illness2 and as the primary manifestation in 20% to 30%.3

Biochemical abnormalities related to adrenal cortex function have been demonstrated to exist in patients with rheumatic fever. These include alterations in the circulating concentrations of certain acute-phase reactants (mucoproteins,* hexosamines,6 and nonglucosamine polysaccharides7) and in the circulating concentrations of adrenal steroids8 and corticotropin (ACTH).9 The purpose of this study was to determine whether similar abnormalities exist in patients with Sydenham's chorea.

MATERIAL AND METHODS  The subjects of this study were 30 children seen at the Salt Lake County General Hospital and in