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May 1955

Intravenous Cholecystography with Cholografin in Infants

Author Affiliations

Cholografin (disodium salt of N,N'-adipyl-bis-[3-amino-2,4,6-triiodo]-benzoic acid) was supplied by E. R. Squibb & Sons, Division of the Mathieson Chemical Corporation.; From the Departments of Pediatrics and Radiology, The Johns Hopkins Hospital, and the Division of Maternal and Child Health, School of Hygiene and Public Health, The Johns Hopkins University.

AMA Am J Dis Child. 1955;89(5):591-595. doi:10.1001/archpedi.1955.02050110705011

This paper reports the use of Cholografin (disodium salt of N,N'-adipyl-bis-[3-amino-2,4,6-triiodo]-benzoic acid) for visualization of the gall bladder in infancy. Cholecystography has been difficult and unsatisfactory in this age group. These preliminary studies are presented because Cholografin appears to be superior to any of the contrast materials previously used for this purpose in the early months of life.

Cholografin is identical with Biligrafin of Schering, A. G., and has been subjected to clinical trials in Germany which were reported in 1953.* Cholografin is a crystalline powder readily soluble to about 20% in water to give a colorless isotonic solution. It has a higher iodine content than other comparable contrast media. Cholografin is given intravenously and is excreted by the liver, the first traces appearing in the bile within a few minutes. The extrahepatic ducts may be visualized in adults within 15 to 20 minutes following injection. Filling of the gall

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