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June 1955

A Pathogenic Type of Escherichia Coli (O111 B4) in Infantile Diarrhea

AMA Am J Dis Child. 1955;89(6):696-700. doi:10.1001/archpedi.1955.02050110836007

Adam,* in 1923 and again in 1927, described organisms of the Bacterium coli group as being etiologically related to infantile diarrhea and proposed the name "dyspepsicoli." Goldschmidt3 placed these organisms in a serological group separate from other members of the coli group. In 1945, Bray4 related B. coli var. neopolitanum to infantile diarrhea, and since then a number of other groups † have extended his observation. They have shown that not only Bray's organism (later typed as O111 by Kaufmann21), but other types of coli can be associated with diarrhea, particularly in premature infants, newborn infants, and infants under 4 to 6 months of age. The results of these studies have emphasized the importance of recognizing this serious problem. The incubation period may vary from 2 or 3 days to as long as 18 days; following this the disease is ushered in by acute findings of anorexia,

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