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December 1955

Studies of Tocopherol Deficiency in Infants and Children: I. Hemolysis of Erythrocytes in Hydrogen Peroxide

Author Affiliations

Sinai Hospital of Baltimore (Dr. Gordon).; From the Ullman Research Laboratory and The Department of Pediatrics, Sinai Hospital of Baltimore, and The Department of Pediatrics, The Johns Hopkins Medical Institutions.

AMA Am J Dis Child. 1955;90(6):669-681. doi:10.1001/archpedi.1955.04030010671002

In 1949, Owens and Owens1 suggested that defective absorption of fat by premature infants * and the use of partially skimmedcows'-milk mixtures † might lead to a deficiency of vitamin E. Support for the latter concept was obtained by Wright, Filer, and Mason,9 who reported that the serum tocopherol levels of premature infants fed partially skimmed cows' milk decreased from average levels of 0.4 mg. per 100 cc. at birth to 0.1 mg. at age 31-40 days. Other investigators reported average levels of 0.25 to 0.5 mg. per 100 cc. for premature infants fed unsupplemented diets,‡ well below the level of approximately 1 mg. per 100 cc. found in full-term infants fed at the breast.9

György and Rose § reported that the erythrocytes of vitamin-E-deficient rats were hemolyzed by suitable incubation with dialuric acid and that this hemolysis was preventable either by feeding tocopherol or by its addition