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December 1955

Ciba Foundation Symposium on Hypertension: Humoral and Neurogenic Factors.

AMA Am J Dis Child. 1955;90(6):757. doi:10.1001/archpedi.1955.04030010759018

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This book is the record of another Ciba symposium which took place in London, in July, 1953. Among the points discussed are reflex blood pressure regulation, the secretion of norepinephrine by the arterial wall, 5-hydroxytryptamine, vasoconstrictor substances, and hexamethonium.

The laboratory diagnosis of pheochromocytoma is reviewed. The occurrence of a significant number of false-positive piperoxan (benzodioxan) and phentolamine (Regitine) tests suggests the use of the more reliable quantitative determination of the amount of epinephrine and norepinephrine in the urine. An additional advantage of the latter is the continued increased excretion of these hormones during normotensive intervals.

Studies on experimental production of hypertension in the rat are particularly interesting. For several days after being made ischemic, the kidney secretes a renal pressor substance; after this period of time the hypertension is maintained by an extrarenal pressor mechanism. This latter phase emerges because the contralateral kidney becomes altered by the initial period

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