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February 1956

A Genetic Study of Celiac Disease: Incidence of Celiac Disease, Gastrointestinal Disorders, and Diabetes in Pedigrees of Children with Celiac Disease

AMA Am J Dis Child. 1956;91(2):131-137. doi:10.1001/archpedi.1956.02060020133005

Celiac disease in more than one member of a sibship has been frequently reported in the medical literature. Thompson in 1951 published a list of the reported cases. There were several instances among twins, siblings, cousins, and even among parents of the propositi.1 Recently it has been observed that, apart from the typical form of celiac disease, there is, among the immediate family and more distant relatives of patients with this condition, a tendency toward a variety of gastrointestinal disturbances. The present investigation represents an attempt to study the type and frequency of such gastrointestinal disturbances.

The incidence of diabetes mellitus in pedigrees of children with celiac disease is believed to be higher than the expected incidence in the general population.* Data on this question were also obtained.

The pedigrees of 50 children with celiac disease and of 50 controls were studied and compared. Because of the known difficulty