[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
April 1956

Muscular Dystrophy: I. History, Clinical Status, Muscle Strength, and Biopsy Findings

Author Affiliations

From the Children's Hospital and the Departments of Pathology, Orthopedics, and Research Medicine of the University of Pittsburgh School of Medicine.

AMA Am J Dis Child. 1956;91(4):326-338. doi:10.1001/archpedi.1956.02060020328002

The etiology of juvenile muscular dystrophy remains obscure despite many decades of clinical and laboratory observations.* The establishment of a program of preventive and remedial care for such patients in this hospital stimulated us to repeat and reassess some of the older observations and to report our findings. The clinical history, spinal fluid findings, motor status, and biopsy material from a group of children with juvenile muscular dystrophy are herein presented.

MATERIAL AND METHODS  Thirty-one children with a history of motor weakness suggestive of muscular dystrophy have been seen in the course of this series of studies. History of the familial incidence of the disease, if any, and of its onset was obtained and the patient's current status established. The strength of muscle groups was evaluated by the physiotherapist (M. J. W.) in accordance with motor function against gravity and against resistance. Biopsies of deltoid and of gastrocnemius muscles were