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April 1956

Muscular Dystrophy: III. Serum and Blood Solutes and Other Laboratory Indices

Author Affiliations

From the Department of Research Medicine, Children's Hospital, University of Pittsburgh School of Medicine.

AMA Am J Dis Child. 1956;91(4):346-355. doi:10.1001/archpedi.1956.02060020348004

It is the general impression that in muscular dystrophy there are no regularly demonstrable abnormalities apart from the oftendescribed changes in creatine and creatinine.* On the other hand, none of the reported observations excluded the possibility of significant mean deviations detectable only upon comparison with suitable control groups. That this is indeed so is evident from studies presented in this paper.

MATERIAL AND METHODS  The following observations were made in a group of 31 children with history, physical examination, muscle biopsy, spinal fluid findings, and radiologic features compatible with the childhood type of muscular dystrophy.†A. Creatine Tolerance Tests.—Serum levels of creatine and creatinine were determined prior to and following the oral administration of creatine ‡ to children with muscular dystrophy and to healthy controls on the per-kilogram-of-body-weight dosage schedule indicated in Figure 2.B. Blood and Serum Solutes.—Fasting levels of blood sugar and nonprotein nitrogen and of serum

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