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April 1956

Muscular Dystrophy: IV. Endocrine Studies

Author Affiliations

From the Children's Hospital and the Department of Research Medicine, University of Pittsburgh School of Medicine.

AMA Am J Dis Child. 1956;91(4):356-364. doi:10.1001/archpedi.1956.02060020358005

Despite early opinion to the contrary, it is now agreed that in muscular dystrophy there are no gross endocrinologic abnormalities. Evaluation of a group of children with muscular dystrophy undertaken in this clinic * provided us with an opportunity to determine the endocrine status of such children by means of some of the newer indices.

MATERIAL AND METHODS  Data based on observations in some but not all the members of a group of 31 children with muscular dystrophy are available. The clinical status of each child, the findings on biopsy of muscles, and the results of roentgenographic, hematologic, blood, serum, urine, and liver studies have been reported in the studies cited earlier †; relative hypercreatinemia was present prior to and at the 145-minute point of creatine tolerance tests. The particular endocrine studies, the techniques employed, and the findings are presented in the section which follows.

RESULTS  A. Pituitary Gonadotropins.—The output