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May 1956

Prednisone in the Treatment of Allergic Disorders in Children: Observations of Plasma 17-Hydroxycorticosteroid Levels

Author Affiliations

Los Angeles; Salt Lake City
From the Children's Medical Group, Los Angeles, the Department of Pediatrics, University of California School of Medicine at Los Angeles, and the Department of Pediatrics, University of Utah School of Medicine, Salt Lake City.

AMA Am J Dis Child. 1956;91(5):454-459. doi:10.1001/archpedi.1956.02060020456006

The steroids and corticotropin have become recognized and generally accepted as valuable adjuncts in the treatment of most allergic conditions. Their limitations and their frequent side-effects, particularly with the prolonged use of these hormones, have been well defined in previous publications.* Recently two new steroids, prednisone † (Meticorten) and prednisolone ‡ (Meticortelone), have been recommended in the treatment of many types of allergic disorders because of their greater antiinflammatory potency and fewer side-reactions. Some of the first reports of these new hormones described their use in the treatment of rheumatoid arthritis.§ Subsequently, several investigators found prednisone to be equally effective in the treatment of bronchial asthma and other atopic allergic conditions.‖ These latter papers, however, reported on the use of prednisone in the treatment of adults.

The purpose of the present communication is to report our clinical experience using prednisone in a small series of allergic children and to present