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June 1956

Neuroblastomas in Infancy and Childhood: A Review of Ten Years' Experience

Author Affiliations

From the Departments of Pathology and Radiology, Children's Hospital, Denver.; Fellow in Pediatric Oncology, Colorado Division American Cancer Society (Dr. Reiquam).

AMA Am J Dis Child. 1956;91(6):588-592. doi:10.1001/archpedi.1956.02060020590012

Neuroblastomas in childhood are usually rapidly fatal. One of the highest survival rates has been reported recently, by Koop and co-workers,2 as 31% for infants surviving 14 months or longer after diagnosis. The result of management of this disease has been so disheartening in spite of occasional reports of recovery that any improvement in survival rates deserves emphasis. The suggestion of Koop and co-workers that treatment consisting of surgical removal or maceration of the tumor results in better survival rates than surgical biopsy followed by x-ray radiation led us to reexamine our case material in the light of the surgical therapy suggested by these authors.

MATERIAL  A total of 25 cases of neuroblastoma, including 15 boys and 10 girls, were studied in Denver Children's Hospital during the past 10 years, 1945 through 1954. Of these cases, 20 (80%) were under 2 years of age, 5 (20%) between 2 and