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July 1956

Penicillin V Treatment of Beta-Hemolytic Streptococcal Infections in Children

Author Affiliations

Rochester, N. Y.
From the Department of Pediatrics, the University of Rochester School of Medicine and Dentistry.

AMA Am J Dis Child. 1956;92(1):20-23. doi:10.1001/archpedi.1956.02060030022006

Introduction  In this report we wish to present the results of the treatment with penicillin V (phenoxymethyl penicillin) of 110 cases of β-hemolytic streptococcal infections in children. This preparation, although discovered in this country in 1947 and used abroad clinically for several years, first became available for clinical trial in the United States in the spring of 1955. Unlike other penicillin salts, its aqueous solution is relatively stable in the acid secretion of the gastric juice. Consequently it passes through the stomach with little change and shows better absorption from the intestinal tract than is found in other preparations of penicillin.1

Methods  All cases were examined by one of us, and a throat culture which grew β-hemolytic streptococci was obtained prior to or at the onset of treatment. In a moderate number of children the culture was repeated within a few days of the beginning of therapy. At the