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July 1956

The Iodized Oil (Lipiodol) Test for Fat Absorption

Author Affiliations

Winnipeg, Man., Canada
From the Departments of Biochemistry and Pediatrics, Faculty of Medicine, University of Manitoba.

AMA Am J Dis Child. 1956;92(1):24-26. doi:10.1001/archpedi.1956.02060030026007

Introduction  Following the use of the administration of iodized oils as a test for fat absorption, Silverman and Shirkey1 introduced a simple modification in which a qualitative test for iodine was performed on varying dilutions of urine collected 12-18 hours following oral ingestion of iodized oil (Lipiodol). They claimed that a positive test for iodine after the ingestion of iodized oil in a dilution of 1 in 4 or greater probably excludes fibrocystic disease of the pancreas as a diagnosis. Our experience with this test was most disappointing, negative results on undiluted urine being often found even with urine of normal controls.We therefore tried the effect of determining the urine iodine quantitatively while preserving the simplicity of the Silverman-Shirkey technique.

Experimental Procedure  Iodized oil was administered to patients in the Children's Hospital, Winnipeg, in the manner described by Silverman and Shirkey. Samples of urine were collected before and

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