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September 1956

Measles Meningoencephalitis: A Summary of Twenty-Four Cases Treated at Grasslands over a Ten-Year Period

Author Affiliations

Valhalla, N. Y.
Resident in Pediatrics, Grasslands Hospital.

AMA Am J Dis Child. 1956;92(3):272-275. doi:10.1001/archpedi.1956.02060030266004

Introduction  The central nervous system complications of measles were recognized as early as 1872, when Westphal first used the term acute disseminated encephalomyelitis. Measles encephalitis as a clinical entity was very adequately described by Neal and Appelbaum, in 1927,4 and by Musser and Hauser, in 1928.7 An increasing interest in the subject of measles encephalitis in recent years has stimulated a search for some form of specific therapy. In 1952, corticotropin (ACTH) was first tried in a series of patients by Appelbaum, at Willard Parker.* Gamma-globulin has subsequently been tried in the treatment of measles encephalitis; however, experience has indicated that it is not an effective therapeutic agent.6The purpose of this presentation is to summarize the experience over a 10-year period with measles meningoencephalitis occurring in the pediatric age group at Grasslands Hospital. There have been 24 diagnosed cases of measles meningoencephalitis treated here since 1945,