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September 1956

III. Correlation of Growth and Morphology of Long Bones with Chemical Growth in Normal and Vitamin D-Deficient Animals

Author Affiliations

Portland, Ore.; San Francisco
Dr. Pickering's present address is Department of Pediatrics, University of Oregon Medical School.; From the Department of Pediatrics, Department of Radiology (Dr. Lusted), and the Department of Pathology (Dr. Crane) of the University of California Medical Center.

AMA Am J Dis Child. 1956;92(3):292-296. doi:10.1001/archpedi.1956.02060030286007

Introduction  This publication presents data pertaining to linear bone growth and morphology in immature male Wistar rats on normal and vitamin D-deficient diets and correlates these data with chemical growth and turnover of the skeleton, previously reported.* Studies involving linear growth, histology, and chemistry of long bones have long been accepted individually as representative indices of the influences of metabolic and endocrine factors upon the skeleton.† However, there has been a paucity of studies correlating these parameters, particularly as they relate to total skeletal chemistry and turnover. The present series of studies were undertaken to provide a correlated chemical, radiological, and morphological interpretation of skeletal growth from birth through 75 days of age in male Wistar rats maintained on normal and vitamin D-deficient diets. Furthermore, these studies bring to focus the observations of earlier workers suggesting that the chemical changes induced in bone by a vitamin D-deficient diet may be