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The chief purposes of the Cooperative Study of Retrolental Fibroplasia (RLF) were to determine, by means of a controlled clinical trial, whether the incidence of RLF was positively associated with the length of exposure of the premature infant to oxygen and whether restricting oxygen to that amount deemed necessary to prevent anoxia would influence the survival rate.The study was designed so that two groups of premature infants received widely different amounts of oxygen while all other factors associated with the care of the infants were kept as similar as possible.There were 786 premature infants in the study. These infants represent all those who were born in or brought to the 18 cooperative hospital nurseries during the study year, who weighed 1500 gm. or less at birth, and who survived 48 hours, at which time they were admitted to the study. Of these infants, 586 were followed for
KINSEY VE, Jacobus JT, Hemphill FM. Retrolental Fibroplasia: Cooperative Study of Retrolental Fibroplasia and the Use of Oxygen. AMA Am J Dis Child. 1956;92(4):395–397. doi:10.1001/archpedi.1956.02060030389009
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