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January 1957

THE SOCIETY FOR PEDIATRIC RESEARCH: Twenty-Sixth Annual Meeting, Buck Hill Falls, Pa., May 7 and 8, 1956

AMA Am J Dis Child. 1957;93(1):7-86. doi:10.1001/archpedi.1957.02060040009002

The Indirect Effect of Irradiation on Rat Embryos.ROBERT L. Brent,* Walter Reed. (Introduced by Gilbert Forbes)

The etiology of congenital malformations is a subject into which only a few inroads have been made. Even in the few cases where agents or environmental conditions are known to be causative, the basic mechanism is still puzzling.

In the past few years a number of workers have produced congenital malformations in mammals with the use of ionizing radiation, (Warkany, Kaven, Hicks, Russel, Rugh, Wilson, and Brent). Except for the experiments of Wilson and Brent, both the maternal organism and the embryos were irradiated, while in their studies only the embryos were irradiated. It had been assumed that all the malformations observed were due to the direct effect of irradiating the embryos and that the radiation effect in the mother played no part in inducing malformations. Wilson and

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