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February 1957

The Aplastic Crisis of Sickle-Cell Disease: Occurrence in Several Members of Families Within a Short Period of Time

Author Affiliations

Washington, D. C.
From the Departments of Pediatrics of the District of Columbia General Hospital and the George Washington School of Medicine.

AMA Am J Dis Child. 1957;93(2):128-139. doi:10.1001/archpedi.1957.02060040130005

The "aplastic crisis" of congenital spherocytic anemia is a well-documented syndrome.1,2 It is known that these erythroblastopenic states may occur in several members of a family within a short period of time. Recently these crises have been also described in sickle-cell anemia.3,4 The purpose of this article is to report on members of two families with sickle-cell anemia in which aplastic crises developed within a short period of time.

Report of Cases 

Family A  Case 1A.—This 5-year-old Negro boy was admitted to the hospital on Nov. 28, 1955. He had been known to have sickle-cell anemia since the age of 5 months. In November and December, 1954, he had had two attacks of cerebral thrombosis leaving him with aphasia and inability to properly handle his oral secretion and a paresis of his left upper extremity. One day prior to admission he was noted to be pale and weak.

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