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February 1957

Renal Function in Children with Leukemia: A Clinical and Pathological Study

Author Affiliations

Washington, D. C.
From The Department of Pathology and The Research Foundation of The Children's Hospital of the District of Columbia.

AMA Am J Dis Child. 1957;93(2):150-156. doi:10.1001/archpedi.1957.02060040152007

Although many authors * have commented on the frequency of parenchymal infiltration of the kidneys in leukemia, there has to date been no systematic study of kidney function during the course of the disease. The purpose of this paper is to present the results of the investigation of renal function in 35 patients with leukemia in the pediatric age group who have been studied during a two-year period, 1954-1955, inclusive.

Clinical results were supplemented by the pathological findings in 14 of the 35 patients who came to postmortem examination.

Methods  Blood urea nitrogen determinations, urinary specific gravity, and routine urinalyses were performed on 35 patients in whom a definite diagnosis of leukemia was established, both by bone marrow and peripheral blood examinations. The blood urea nitrogen was performed by a spectrophotometric method using glycerol urease.7 By this method values from 10 to 16 mg/100 ml. are considered within the range

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