With the development of increasingly precise criteria for the various types of hemolytic disease and of hepatic disease, the role of these disorders in the causation of neonatal jaundice has become greatly clarified. By the same token, it has become possible to delineate a residual group of hyperbilirubinemias in the newborn period, the cause and mechanism of which still remain obscure. This study is designed to call attention to the problems presented by this group because it is pertinent to the definition of physiologic jaundice and because of the probable relationship of hyperbilirubinemia to kernicterus.
This report concerns 50 patients, about half of them full-term infants, seen in a pediatric hospital during a period of nine months, who had bilirubinemia significantly in excess of levels currently considered normal for "physiologic" jaundice and who came to our attention because of early or excessive clinical jaundice or both. Only those infants were
BROWN AK, ZUELZER WW. Studies in HyperbilirubinemiaI. Hyperbilirubinemia of the Newborn Unrelated to Isoimmunization. AMA Am J Dis Child. 1957;93(3):263–273. doi:10.1001/archpedi.1957.02060040265012
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