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May 1957

Studies on Familial Nephrosis: I. Clinical and Pathologic Study of Four Cases in a Single Family

Author Affiliations

Postdoctorate Fellow of the U. S. Public Health Service (Dr. Vernier).; American Legion Memorial Heart Research Professor of Pediatrics (Dr. Good).; From the Pediatric Research Laboratories of the Variety Club Heart Hospital and the Department of Pathology, University of Minnesota.

AMA Am J Dis Child. 1957;93(5):469-485. doi:10.1001/archpedi.1957.02060040471001

The nephrotic syndrome has rarely been observed in more than one member of a family and is not generally considered to be a familial disease. Prader1 and Goettsch,2 however, reported the occurrence of the nephrotic syndrome in twins. Barnett3 has observed nephrosis in two siblings of three families and Werner4 in siblings of two additional families. Recently Fanconi5,6 summarized the experience of his clinic with regard to the familial incidence of the nephrotic syndrome in 17 children of seven families. He concluded that nephrosis may occur as a familial disease and that the disease tends to be severer in older members of the family. He also stated that the prognosis of familial nephrosis seemed to be worse than that usually accorded the sporadic form of nephrosis.

This report presents the results of a study of a family in which all four children suffered from the

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