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June 1957

I. Clinical Results and Effects on Proteinuria in One Hundred Six Instances

Author Affiliations

From the University of Pittsburgh School of Medicine and the Children's Hospital of Pittsburgh. Established Investigator of the American Heart Association (Dr. Mateer).

AMA Am J Dis Child. 1957;93(6):591-603. doi:10.1001/archpedi.1957.02060040593001

Intially corticotropin (ACTH) and cortisone were used only to induce diuresis in children with the nephrotic syndrome, though occasional remissions were produced.1-7 Most of these early trials were of short duration and the amounts of drugs administered were small because of limited supplies and the occurrence of side-effects such as edema, hypertension, and hypokalemia. The demonstration that such changes could be prevented or minimized by means of diets rigidly restricted in sodium and high in potassium8 enabled us and others9,10 to undertake more prolonged administration of large amounts of corticotropin and adrenocortical steroids in the hope of influencing the course of the underlying disease.

Materials and Methods  During the past five years we have treated a total of 106 instances of nephrotic syndrome in children. All had persistent and usually massive proteinuria on admission. Each patient was treated in essentially the same way, and no attempt was