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July 1957

Plasma Inorganic Phosphate and Glucose of Prepubertal Children Taking Testosterone

Author Affiliations

From the National Institutes of Health, Bethesda, Md., and the Jefferson Medical College of Philadelphia, Department of Pediatrics.

AMA Am J Dis Child. 1957;94(1):6-11. doi:10.1001/archpedi.1957.04030020008002

It has been known for many years that the inorganic phosphate concentration of plasma is elevated in early life.1-5 The high values found during the newborn period may result from a relatively high phosphorus intake, temporary neonatal hypoparathyroidism, low glomerular filtration rate, or a failure of the renal tubule to respond to parathyroid hormone.1-5 After the first year of life, however, the elevation has been attributed by many to the presence of a high concentration of growth hormone.6-9

Hamilton, Bunch, Mestler, and Imagawa recently reported that after orchiectomy the plasma inorganic phosphate of young adults rose to the prepubertal level within one to three weeks.10 They interpreted their data, and those from the literature, as indicating that sex hormones exert a depressant effect on the plasma phosphate concentration and concluded that sex hormones, rather than a decreasing concentration of growth hormones, may depress the phosphate concentration during