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July 1957

Juvenile Cirrhosis: A Clinico pathologic Study of Twenty-Seven Cases

Author Affiliations

Rochester, Minn.
Mayo Foundation, Fellow in Pediatrics (Dr. Ruggieri); Mayo Clinic and Mayo Foundation, Section of Pathologic Anatomy (Dr. Baggenstoss) and Section of Pediatrics (Dr. Logan). The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Am J Dis Child. 1957;94(1):64-76. doi:10.1001/archpedi.1957.04030020066012

The pathogenesis of hepatic cirrhosis has been in dispute since Laennec first wrote his account of the disease in 1819. The many studies made to solve this problem attest to its difficulty. This difficulty of determining pathogenesis has been as great for the juvenile form as it has been for the adult form of the disease. In order to contribute to our knowledge of the pathogenesis and other aspects of juvenile cirrhosis, all cases studied at the Mayo Clinic which had pathologic verification were reviewed and a careful study was made of the clinical and pathologic aspects of the disease. Some of the cases previously studied by Perozzi have been included.

Material and Methods  Cirrhosis is defined as that condition of the liver which fulfills the following criteria: (1) degeneration of hepatic cells, (2) increase in connective tissue, and (3) the presence of nodular regeneration with distortion of the vascular

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