The pathogenesis of hepatic cirrhosis has been in dispute since Laennec first wrote his account of the disease in 1819. The many studies made to solve this problem attest to its difficulty. This difficulty of determining pathogenesis has been as great for the juvenile form as it has been for the adult form of the disease. In order to contribute to our knowledge of the pathogenesis and other aspects of juvenile cirrhosis, all cases studied at the Mayo Clinic which had pathologic verification were reviewed and a careful study was made of the clinical and pathologic aspects of the disease. Some of the cases previously studied by Perozzi have been included.
Material and Methods
Cirrhosis is defined as that condition of the liver which fulfills the following criteria: (1) degeneration of hepatic cells, (2) increase in connective tissue, and (3) the presence of nodular regeneration with distortion of the vascular
RUGGIERI BA, BAGGENSTOSS AH, LOGAN GB. Juvenile Cirrhosis: A Clinico pathologic Study of Twenty-Seven Cases. AMA Am J Dis Child. 1957;94(1):64–76. doi:10.1001/archpedi.1957.04030020066012
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