The nephrotic syndrome is an easily recognized condition which is manifested by edema, albuminuria, hypoalbuminemia, and hyperlipemia. The characteristic histological lesion consists of thickening and splitting of the basement membrane of the glomerular tufts with secondary tubular degeneration and lipoid deposition.1 Renal-clearance studies have shown variable results in the acute phase of the disease and moderately to greatly diminished function in the chronic stages.2,3 The disease is commonest between 18 months and 4 years, although occasional cases are seen in other age groups. We have had the opportunity recently to study an infant who developed the first signs of nephrosis at 15 days of life. This is the third such case reported 4,5 of the nephrotic syndrome in the neonatal premature infant and the first in which renal-clearance measurements have been made during the course of the disease process. Such a case may contribute information as to the
GRUSKAY FL, TURANO A. Nephrosis in the Newborn Infant: A Syndrome Difficult to Explain by Existing Theories of Etiology. AMA Am J Dis Child. 1957;94(2):117–122. doi:10.1001/archpedi.1957.04030030011003
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.