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September 1957

Use of Chlorpromazine in Two Hundred Seventy-Eight Mentally Deficient Patients

Author Affiliations

Pomona, Calif.
From Pacific State Hospital and the Departments of Psychiatry and Pediatrics, University of California School of Medicine at Los Angeles.

AMA Am J Dis Child. 1957;94(3):294-300. doi:10.1001/archpedi.1957.04030040080013

The use of chlorpromazine* as a tranquillizer in the treatment of major psychiatric symptoms has frequently been reported.1-12 Less information is available, however, on its use in controlling behavior disturbances in the mentally deficient patient.13-17 Bonafede noted a reduction in irritability, hostility, and aggressiveness in 75 mental defectives with epilespsy who were given chlorpromazine. There was no reduction in the number of seizures.13 Bair and Herold reported an improvement in I. Q., general behavior, and sleep patterns in 10 hyperactive retarded children given chlorpromazine.14 Improved manageability of overactive and destructive patients was noted by Rettig, as well as a lessening of disciplinary and custodial duties of the hospital personnel.15 Both MacColl and Horenstein have reported significant degrees of improvement in the behavior of treated patients.16,17

The purpose of this presentation is to report our experiences with chlorpromazine in treating behavioral symptoms in 278 mentally deficient

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