Cushing's syndrome in infancy is very rare. Recently, Guin and Gilbert reviewed 28 cases of adrenal cortical carcinoma associated with this syndrome in persons less than 14 years old.1 They added one case, with onset at 6 weeks. In only 2 of the 29 cases did the symptoms appear before the age of 6 months. In reviewing the literature the impression is gained that Cushing's syndrome in the pediatric age group is usually caused by an adrenal tumor. Albright and Forbes were of the opinion that all such cases in infancy are caused by malignant tumors.2 Forsham and Thorn also believed that the adrenal lesion was oftenest a malignant one when the disease appeared before puberty.3 However, Powell cites two instances due to adrenal cortical adenoma within the first year of life.4,5 Furthermore, Talbot et al. claim that bilateral adrenal hyperplasia is more commonly the cause
GREENBLATT RB, MANAUTOU JM, ZIMMERMAN AM, LUCAS WT. Cushing's Syndrome in Infancy. AMA Am J Dis Child. 1957;94(6):691–695. doi:10.1001/archpedi.1957.04030070103012
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