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March 1958

Isolation of ECHO Virus Type Two from the Cerebrospinal Fluid in Aseptic Meningitis

Author Affiliations

From the Departments of Bacteriology and Immunology and of Pediatrics, University of Buffalo School of Medicine, and Statler Research Laboratories of the Children's Hospital. Markle Scholar in Medical Science (Dr. Karzon); present address: 2625 Poplar St., Denver 7 (Mrs. Pollock).

AMA Am J Dis Child. 1958;95(3):235-239. doi:10.1001/archpedi.1958.02060050237001

The significance of the ECHO (enteric cytopathogenic human orphan) viruses in the etiology of human disease, particularly in the syndrome of aseptic meningitis, is gradually being defined. Of 14 original ECHO virus serotypes, only 6 were isolated from the intestinal tracts of sporadic cases of aseptic meningitis. The remainder were isolated from the intestinal tracts of well persons. The demonstration of the prevalence of ECHO viruses in the healthy population has resulted in a need for more rigorous proof of the etiologic relationship of each serotype with human disease. Such evidence has already been presented for certain ECHO virus types, i. e., ECHO virus Type 6,1 Type 4,2 and Type 9,3 each of which has been studied in epidemic situations. This report concerns the isolation of ECHO virus Type 2 from the cerebrospinal fluids of two related persons with aseptic meningitis in Buffalo and presents evidence for