During the fourth week of June, 1956, strains of coagulase-positive hemolytic Staphylococcus pyogenes var. Aureus (Micrococcus pyogenes var. Aureus), apparently highly virulent for infants, were isolated from seven patients either at the time of admission to The Children's Hospital, Cincinnati, or shortly thereafter. Six of these patients were critically ill, four with pneumonia and empyema, one with pneumonia and a large deep intramuscular abscess, and one with pneumonia. The seventh infant was seriously ill with a large abscess. Our attention was attracted not only by the unusual number of infants with pneumonia at that season of the year but also by their critical clinical condition. One of the critically ill infants with pneumonia and empyema died on the second hospital day, and postmortem cultures from lung, empyema fluid, and middle ear were positive for coagulase-positive hemolytic S. pyogenes var. aureus. A second critically ill infant with pneumonia and empyema was
COOPER ML, KELLER HM, Wegman JC, Perry EW, Sassi AH, Partin JC. Severe Staphylococcal Infections in Young Children: The Isolation of Micrococcus Pyogenes Var. Aureus with a Specific Bacteriophage Pattern. AMA Am J Dis Child. 1958;95(3):245–252. doi:10.1001/archpedi.1958.02060050247003
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