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March 1958

Die Pathogenese des Morbus haemolyticus neonatorum.

AMA Am J Dis Child. 1958;95(3):338. doi:10.1001/archpedi.1958.02060050340028

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This small book is essentially a review of previous work on the mechanism of sensitization in erythroblastosis fetalis along with experimental work done by the author in this field. A series of experiments, designed to demonstrate Rh-substance in macerated placenta, are reported.

After careful washing of macerated placental tissue, the author was unable to demonstrate any Rh-substance in the tissue. He considers that the placenta acts only as a neutral barrier between the mother and fetus. The author also discusses his own experiments and those of others in regard to the possibility of Rh-sensitization by previous serum injections and concludes that we have inadequate information about this, as such sera may contain some sensitizing red blood cells.

The author believes that with the first delivery there is an entry of fetal red blood cells into the maternal circulation, with resulting sensitization. In subsequent pregnancies small amounts of fetal red blood

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