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May 1958

Promazine Modification of Reflex Rigidity in a Decerebrate Child

Author Affiliations

South Orange, N. J.
From the Babies' Hospital-Coit Memorial, Newark, N. J.

AMA Am J Dis Child. 1958;95(5):534-537. doi:10.1001/archpedi.1958.02060050538011

The subcortical depressants, especially the phenothiazine derivatives, appear to possess a multiplicity of pharmacological properties and have been used in a variety of clinical disturbances.1-3 From the body of pharmacological evidence accumulated, it is fairly apparent that certain of these compounds block the afferent pathways to the reticular area and exert a selective influence primarily on the diencephalon.4,5

A 19-month-old girl was admitted to the Babies' Hospital-Coit Memorial, Newark, N. J., at 12:45 a. m., on Feb. 7, 1956, in status epilepticus. She had had an elevation of temperature of mild degree, diarrhea, and vomiting and she had refused all liquids and taken no food for two days. Two weeks previously a similar episode, lasting two days, had occurred. She started to have generalized convulsions just prior to hospitalization and continued to convulse for several hours after admission. On cessation of the seizures the patient remained in a