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August 1958

Dietary and Storage Factors in Iron-Deficiency Anemia of Infancy

Author Affiliations

From the Rh Laboratory and Tufts Hematology Unit, Boston City Hospital. Public Health Service Research Fellow of the National Heart Institute and Assistant in Medicine, Tufts Medical School (Dr. Dawson); Physician-in-Charge, Rh Laboratory, Boston City Hospital, and Assistant Professor of Medicine, Tufts Medical School (Dr. Desforges).

AMA Am J Dis Child. 1958;96(2):169-178. doi:10.1001/archpedi.1958.02060060171007

Several factors are thought to contribute to the iron-deficiency anemia of infancy. Included among these are decreased dietary iron, inadequate iron stores at birth, and excessively rapid growth. This study was undertaken to evaluate the relative importance of these factors.

Methods and Materials  The peripheral blood was studied in all infants, as previously described,1 with the exception of some hemoglobin determinations, which were measured with use of a modification of the cyanomethemoglobin method.2 Serum iron and iron-binding capacity were measured by the method of Peters et al.3,4 as modified from the Barkan and Walker procedure.5Seventy-seven infants with iron-deficiency anemia were studied during the years 1954 to 1956. The general physical condition of the infants was evaluated. Where possible, careful histories were taken, with special reference to age, sex, race, birth weight, present weight, diet, and blood loss. Inquiries were also made into maternal history of

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