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September 1958

Clinical Enzymology.

AMA Am J Dis Child. 1958;96(3):416. doi:10.1001/archpedi.1958.02060060418024

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For many of us practicing physicians the term "enzymes" refers to vague chemical substances found in the laboratories of the biochemists. Many use the term as an even more vague explanation for certain phenomena. How often does one hear the following: "No one knows what the explanation is. It must be an enzyme"!

It is an arresting experience, therefore, to come across a book with the title "Clinical Enzymology," and it is impressive to read how much of clinical science from both the diagnostic and therapeutic aspects is directly involved with enzymology today. Consider, for example, the parenteral use of trypsin in occlusive peripheral vascular disease. The book presents impressive "before and after" pictures illustrating its use parenterally in cases of decubitus ulcers, thrombophlebitis, and varicose ulcers. However, as in many other fields, the interpretation of the results of studies in which this agent was used are not always clear

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