Adrenal tumors in children under 10 years of age are relatively rare. In 1951 one of us (R. B. G.) placed on record a case of a virilizing adrenal tumor in a 3-year-old girl1 and in reviewing the literature found 76 previously reported cases. From the time of that report until 1957, there have been approximately 30 additional cases.2-26 In the interim, primarily as a result of an increased understanding of adrenal physiology, there has been considerable improvement in the techniques for the diagnosis of adrenocortical tumors.
As early as 1950, Wilkins27,28 reported that the administration of cortisone suppressed the excretion of androgens in congenital adrenal hyperplasia, and he suggested the use of cortisone in the treatment of this condition.29 The suppression of 17-ketosteroid excretion by cortisone was proposed as a test to aid in differentiating between adrenocortical tumor and hyperplasia.30
The findings of Wilkins
SCARPA-SMITH C, THORNTON N, CAFFERY EL, GREENBLATT RB. Virilizing Adrenal Tumors in Children. AMA Am J Dis Child. 1959;97(1):78–86. doi:10.1001/archpedi.1959.02070010080007
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