Although the number of patients admitted to the James Whitcomb Riley Hospital because of diarrheal dehydration has remained fairly constant during the past several years, the percentage of such patients who had hypernatremic (hypertonic) dehydration has increased steadily. The present study was undertaken to determine whether this increased incidence of hypernatremic dehydration was associated with factors in the therapy administered prior to referral to this hospital and if, as such, it reflected some changes in the manner in which the physicians of this state treated severe diarrhea. The four factors considered as possibly associated with hypernatremic dehydration were (1) the presence of preexisting brain damage; (2) the administration of parenteral fluids either intravenously or, as was usually the case, subcutaneously; (3) the use of noncommercial oral electrolyte solutions (O. E. S.), and (4) the use of a commercially available oral electrolyte preparation, Lytren (Mead Johnson & Company).
FRANZ MN, SEGAR WE. The Association of Various Factors and Hypernatremic Diarrheal Dehydration. AMA Am J Dis Child. 1959;97(3):298–302. doi:10.1001/archpedi.1959.02070010300006
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