Difference between the hemoglobins of the fetus and the adult was first demonstrated by Körber in 18661 and has been found in all species subsequently studied. Distinctions between the two hemoglobins have been demonstrated by several methods, particularly resistance to alkaline denaturation,2 chemical structure,3 immunological properties,4 behavior of monomolecular layers,5 and electrophoretic mobility.6
The oxygen dissociation curves were first investigated by Huggett7 in 1927, who found that the curve of blood from the goat fetus "did not resemble the curves measured on the bloods of adults of other species, which might indicate the presence of an unusual form of hemoglobin." Barcroft and his co-workers8 (1934) studied the degree of inflection and the position of curves from fetal and maternal blood in the goat at weekly intervals in the later stages of pregnancy. The dissociation curve of fetal blood not only lay to
ABRAHAMOV A, SMITH CA. Oxygen Capacity and Affinity of Blood from Erythroblastotic Newborns: I. Effects of Plasma Environment on Erythrocytes Containing Fetal or Adult Hemoglobin. AMA Am J Dis Child. 1959;97(4):375–379. doi:10.1001/archpedi.1959.02070010377001
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