The anti-Rh antibody first found in human serum was an agglutinin active, like other agglutinins, against erythrocytes suspended in saline, but, unlike most other blood group antibodies, more active at 37 C, than at lower temperatures. It can be absorbed by red cells and eluted from them, and apart from the complicated specificities involved, does not differ particularly from other antibodies.1
In addition to the saline agglutinin, there is a type of antibody incapable of agglutinating erythrocytes suspended in saline, but combining with cells containing the proper receptor, and thus rendering them insusceptible to agglutination by the ordinary saline agglutinins. These antibodies were therefore first referred to as "blocking" or "coating" antibodies. The presence of anti-Rh antibodies on the red cells somehow causes them to be removed from the circulation and destroyed earlier than normally.2 The red cells appear normal in the test tube, and even on microscopic
ABRAHAMOV A, DIAMOND LK. Reduction of Oxygen-Carrying Capacity of Rh-Postive Erythrocytes Coated with Anti-D Antibodies. AMA Am J Dis Child. 1959;97(4):380–383. doi:10.1001/archpedi.1959.02070010382002
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