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May 1959

Muscular Dystrophy: X. Endocrine and Electrolyte Effects of Methyltestosterone-KCl Therapy

Author Affiliations

From the University of Pittsburgh School of Medicine and the Shadyside Hospital.

AMA Am J Dis Child. 1959;97(5_PART_I):555-560. doi:10.1001/archpedi.1959.02070010557004

The administration of methyltestosterone and potassium chloride to patients with muscular dystrophy in an unsuccessful attempt to modify the downward course of the muscle debility provided an opportunity to assess the effects of this androgen upon certain endocrine indices.

Materials and Methods  Clinical and other pertinent data on the 13 boys and 2 men receiving approximately 10 mg. of methyltestosterone as buccal Linguets and 1 to 3 gm. of potassium chloride per os daily for 12 to 24 months have been presented earlier.1 At the end of the therapeutic trials, and in some instances prior to and during their course, roentgenograms of the sella turcica, the urinary excretion of pituitary gonadotropins,2 17-hydroxycorticosteroids,3,4 and 17-ketosteroids,5,6 the level of serum protein-bound iodine,7,8 the blood and serum solutes, and the responses of the blood sugar and serum inorganic phosphorus to dextrose,9 to insulin,9 and to epinephrine